Tourism and its related economy are currently undergoing transformation and are recognized as one of the main pillars of the global commercial economy, playing a vital role in the world economy. Furthermore, many economic development planners and policymakers refer to the tourism industry as a cornerstone of development. Tourism-related activities and the provision of appropriate services in a region, like many economic sectors, require certain foundational prerequisites. Therefore, the importance of the tourism industry on one hand, and the existence of tourism potentials in Isfahan province on the other, necessitate the use of a suitable method for prioritizing the different areas of this province. This is essential for effective and efficient planning and for prioritizing various investments in these regions. In this study, using the Topsis model, we evaluated and prioritized the cities of this province based on tourism development indicators (including the extent of natural attractions, historical-cultural attractions, man-made attractions, number of hotels, number of restaurants, number of travel agencies, railway stations, bus terminals, airports, campsites, and number of sample tourism areas). The cities were classified into four levels: highly developed, developed, moderately developed, and underdeveloped. The research method is descriptive-analytical, and the data collection method is library-documentary based. The results of the study show that among the cities of the province, Isfahan, Kashan, Semirom, Fereydunshahr, Mobarakeh, Natanz, Nain, Khur, and Ardestan are classified at the developed level..